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動物疾病現(xiàn)貨模型

Animal Disease Available
糖尿病及并發(fā)癥研究 肥胖及脂肪肝研究 心腦血管疾病研究 腫瘤與代謝研究 動物疾病現(xiàn)貨模型 動物表型檢測 分子生物學(xué)及病理檢測 其他疾病模型研究
ApoE KO自發(fā)動脈粥樣硬化硬化小鼠模型
發(fā)布時間: 2022-05-02 瀏覽量： 次

項(xiàng)目介紹：

簡稱：ApoE(動脈粥樣硬化小鼠模型）

品系類型：基因敲除

來源：南京大學(xué)模式動物研究所

繁殖方式：陽性（T）♂×陽性（T）♀


應(yīng)用領(lǐng)域：


1. 糖尿病和肥胖研究

2. 神經(jīng)生物學(xué)研究

3. 心血管研究

4. 藥效評價


背景介紹：


年老的ApoE基因缺陷小鼠（大于17個月）在腦部晶狀膽固醇裂隙，脂質(zhì)滴和泡沫細(xì)胞中有黃瘤的損害，小的黃瘤在脈絡(luò)叢和腹側(cè)彎中能看到。最近研究表明ApoE缺陷小鼠對應(yīng)激、減弱的學(xué)習(xí)與記憶，改變的長期增強(qiáng)效應(yīng)，突觸的損害等都有反應(yīng)。西方膳食會誘導(dǎo)小鼠產(chǎn)生脂肪紋


飲食誘導(dǎo)動脈粥樣硬化的APOE和LDLR小鼠模型對比

ApoE KO自發(fā)動脈粥樣硬化硬化小鼠模型(圖1)

價格體系：


ApoE KO自發(fā)動脈粥樣硬化硬化小鼠模型(圖2)


項(xiàng)目案例：


ApoE KO自發(fā)動脈粥樣硬化硬化小鼠模型(圖2)

Hyperlipidemia and atherosclerosis in double-knockout NOD Apoe ?/? Ldlr ?/? mice. (A) Kinetics of body weight of NOD Apoe ?/? Ldlr ?/? and B6 Apoe ?/? mice fed a HFD for 20 weeks, with NOD and B6 wild-type controls. For each time point, at least three animals were analyzed for each genotype (n=3-55). (B) Blood cholesterol (TC), triglyceride (TG), high-density lipoprotein (HDL) and low-density lipoprotein (LDL) concentrations of mice on normal diet for 20 weeks analyzed in two independent experiments involving NOD Apoe ?/? Ldlr ?/? and NOD control mice (n=8-19). 'in [mmol/L]', the levels of TC, TG, LDL and HDL were measured in mmol/l. (C) Blood TC, TG, HDL and LDL concentrations of mice on a HFD for 20 weeks analyzed in two independent experiments involving NOD Apoe ?/? Ldlr ?/? and NOD mice (n=4-11). (D) Representative images of Oil-Red-O-stained aortas of mice on a HFD for 4, 8 and 20 weeks (en face assay). (E) Quantitative analysis of en face lesion area of NOD Apoe ?/? Ldlr ?/? and B6 Apoe ?/? mice fed a HFD for 20 weeks, with NOD and B6 wild-type control mice [NOD, n=6 (male=3, female=3); NOD Apoe ?/? Ldlr ?/? , n=23 (male=10, female=13); B6, n=6 (male=3, female=3); B6 Apoe ?/? , n=13 (male=4, female=9)]. Data were collected from two independent experiments with the same animals used in D (n=6-23). (F) Four representative microscopy images of aortic root sections from NOD Apoe ?/? Ldlr ?/? and B6 Apoe ?/? mice placed on a HFD for 20 weeks, with controls of NOD and B6 wild-type mice. Scale bars: 400 μm. (G) Quantitation of plaque area relative to the area of the aortic lumen from F


參考文獻(xiàn)：

A severe atherosclerosis mouse model on the resistant NOD background.Dis Model Mech 2018 10 08;11(10)